Hyaluronic acid-based reduction responsive nanoparticles for Improved anti-psoriasis effects of traditional Chinese herb monomer oleanolic acid via blocking YAP-AREG axis - PubMed
4 days ago
- #Psoriasis
- #Hyaluronic acid
- #Nanoparticles
- Oleanolic acid (OA) shows anti-psoriatic potential but has poor solubility and bioavailability.
- Hyaluronic acid-based nanoparticles (OA-NPs@OA) were developed to improve OA delivery.
- OA-NPs@OA enhanced cellular uptake via CD44 receptor-mediated endocytosis in keratinocytes.
- In a murine model, OA-NPs@OA showed superior transdermal penetration and lesional retention.
- OA-NPs@OA reversed psoriatic phenotypes, reduced PASI scores, and normalized epidermal thickness.
- Mechanistically, OA-NPs@OA blocked the YAP-AREG pathway and downregulated chemokine networks.
- OA-NPs@OA demonstrated excellent biosafety with no dermal or systemic toxicity.
- The study concludes OA-NPs@OA is a novel targeted nanotherapy for psoriasis with enhanced efficacy and safety.