CENPA as a Genome Stability-Associated Biomarker in Hepatocellular Carcinoma: Multiomics Analysis and Experimental Validation - PubMed
2 hours ago
- #genomic instability
- #cisplatin sensitivity
- #CENPA
- CENPA is identified as a genome stability-associated biomarker in hepatocellular carcinoma (HCC) through multiomics analysis.
- CENPA expression is upregulated in HCC tissues and correlates with advanced clinicopathological features and unfavorable survival outcomes.
- Functional analysis shows CENPA is linked to cell-cycle activity, DNA repair, and DNA damage-related programs in HCC.
- CENPA knockdown in vitro suppresses HCC cell proliferation, clonogenic growth, and migration.
- CENPA depletion increases cisplatin sensitivity, reduces IC50 values, and induces G2/M accumulation in HCC cell models.
- The study suggests CENPA is a functional contributor to malignant phenotypes in HCC and may have translational significance for genotoxic stress response.