Silibinin alleviates lung fibrosis by targeting Annexin A6 to suppress endoplasmic reticulum stress and oxidative stress - PubMed
5 hours ago
- #silibinin
- #Annexin-A6
- #pulmonary-fibrosis
- Silibinin (SIL) alleviates lung fibrosis by targeting Annexin A6 (ANXA6).
- SIL suppresses endoplasmic reticulum (ER) stress and oxidative stress in lung fibroblasts.
- The study used BLM-induced pulmonary fibrosis in mice and TGF-β1-induced fibroblast activation models.
- Limited proteolysis-mass spectrometry (LiP-MS), molecular docking, and SPR identified ANXA6 as SIL's direct target.
- ANXA6 knockdown reduced TGF-β1-induced ROS, ER stress, and fibroblast activation, while overexpression worsened them.
- SIL binding to ANXA6 inactivates the PI3K/AKT/mTOR pathway, mitigating fibroblast activation.
- ANXA6 is proposed as a therapeutic target for pulmonary fibrosis, with SIL as a natural inhibitor.