Three-Year Follow-Up of the PACI Randomized Controlled Trial (PACI-ON): Effects of Early Intervention for Atopic Dermatitis on Atopic March - PubMed
a day ago
- #food allergy
- #atopic dermatitis
- #early intervention
- Early enhanced topical corticosteroid (TCS) therapy for atopic dermatitis (AD) in infancy modestly reduced food allergy (FA) prevalence at 28 weeks, with effects persisting to age 3 years.
- At age 3, the early enhanced group had a lower prevalence of any FA (47.4% vs. 58.8%) and raw egg allergy (30.4% vs. 40.5%) compared to the conventional group.
- No significant differences were observed between groups for wheeze, asthma, or rhinitis by age 3.
- Japanese cedar sensitization was lower in the enhanced group at age 2 but not at age 3.
- AD control and quality of life were well maintained in both groups, with over 90% achieving mild or less severe disease.
- Early growth suppression observed at 1 year resolved by age 3, indicating no long-term safety concerns.
- The study supports early AD treatment as a potential strategy to modify allergic disease trajectories, though most differences were small.