Comprehensive Analysis of IgA Nephropathy Causal Factors in Plasma Proteins, Immune Cell Types and Immune Cell Traits - PubMed
14 hours ago
- #IgA nephropathy
- #immune traits
- #Mendelian randomization
- IgA nephropathy (IgAN) is the most frequent primary glomerular disease worldwide, often leading to end-stage kidney disease.
- A Mendelian randomization phenome-wide association study (MR-pheWAS) was conducted to identify causal factors of IgAN, analyzing plasma proteins, immune cells, and immune cell traits.
- Complement factor H (CFH) was identified as a protective factor, while CFHR1 and ERAP2 were identified as risk factors for IgAN.
- Higher neutrophil counts and certain CD4+ T cell subsets were associated with increased IgAN risk.
- Single-cell transcriptomic analysis revealed elevated expression of specific genes in mesangial cells from IgAN patients.
- Mice experiments showed elevated levels of PYDC1, caspase1, NLRP3, and IL1β in IgAN kidneys.
- The study highlights the importance of complement components and specific immune traits in IgAN pathogenesis, suggesting targets for future research and therapy.