Blood biomarkers for the diagnosis of chorioamnionitis following preterm premature rupture of membranes: a systematic review and meta-analysis of studies since 2020 - PubMed
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- #Blood Biomarkers
- #Chorioamnionitis
- #PPROM
- PPROM is spontaneous fetal membrane rupture before 37 weeks, and diagnosing chorioamnionitis early is crucial to prevent maternal and fetal complications.
- Current nonspecific biomarkers like CRP and WBC lack accuracy, prompting a systematic review of recent studies to identify or evaluate new blood biomarkers.
- Meta-analysis of 9 selected studies showed moderate diagnostic performance: sensitivities ranged 71-83% and specificities 41-82% for CRP, WBC, PCT, and NLR.
- No single biomarker accurately predicts chorioamnionitis, with AUC values between 73-77%, and no new biomarkers have been sufficiently studied for meta-analysis.
- Future research should focus on discovering new predictive biomarkers, possibly through large-scale proteomic approaches, to improve diagnosis and management.