Liver-Targeted Gallium-Polyphenol Network by Disrupting the ROS/NETs/PANoptosis Axis for Precision Acute Liver Injury Therapy - PubMed
5 hours ago
- #nanotherapy
- #acute liver injury
- #PANoptosis
- A new study identifies the ROS/NETs/PANoptosis axis as a central driver of hepatocyte damage in acute liver injury (ALI).
- Researchers engineered a liver-targeted gallium-quercetin nanocomposite (Ga@Que) to therapeutically target this axis and overcome quercetin's poor bioavailability.
- In mouse models, Ga@Que accumulated in the liver, scavenged ROS, suppressed neutrophil infiltration and NETs formation, and attenuated PANoptosis.
- Ga@Que treatment mitigated liver damage and inflammation, outperforming its individual components, and offers a promising precision nanotherapeutic strategy for ALI.