Mitochondrial NADH-redox inflexibility constrains genomic and epigenetic stability in pluripotent stem cells - PubMed
2 hours ago
- #Pluripotent stem cells
- #Mitochondrial metabolism
- #Redox biology
- ETC inhibition causes NADH reductive stress in pluripotent stem cells, driven by TDH.
- Reductive stress leads to metabolic pausing, maintaining genomic/epigenetic stability.
- Inhibition of one-carbon metabolism enzymes (SHMT1/2, MTHFD2) reduces stress and rescues pausing in hPSCs.
- Limited mitochondrial redox adaptability is a conserved feature of pluripotent stem cells.