Environmental exposure to perfluorooctanoic acid promotes early gastric carcinogenesis via PPAR-γ-mediated ferroptosis - PubMed
5 hours ago
- #Ferroptosis
- #PFOA
- #PPAR-γ
- PFOA exposure promotes early gastric carcinogenesis via PPAR-γ-mediated ferroptosis.
- Network toxicology identified the PPAR pathway as a key driver linking PFOA exposure to gastric cancer progression.
- Cell experiments showed that PPAR and ferroptosis inhibitors protect gastric cells from PFOA-induced ferroptosis.
- Animal experiments used three PFOA concentrations, with environmental human dosage translated to the lowest mouse dosage.
- RNA-seq analysis revealed PPAR-γ as a differentially expressed gene, downregulated in all PFOA exposure groups.
- Organoid experiments confirmed PFOA-induced PPAR-γ downregulation and increased cancer marker P53 after 5 days.
- The study highlights an overlooked gastric liability in PFOA health risk assessments.