Longitudinal profiling reveals immune dynamics and distinct plasma cell signatures during B-cell depletion in IgG4-related disease - PubMed
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- #IgG4-related disease
- #Plasma cell signatures
- #B-cell depletion
- Study conducted longitudinal multi-omics analysis on IgG4-related disease (IgG4-RD) patients undergoing rituximab therapy.
- Identified a disease-specific IgG4+ plasma cell subset expressing neuropeptide NMU and skewed IGHV1-69 usage.
- Found expanded double-negative T cells (dnT) expressing IL10, suggesting involvement in immune regulation.
- Circulating follicular helper T cells (CD4+Tfh) showed signs of chronic antigen stimulation linked to disease.
- NMU-expressing IGHV1-69+ plasma cells are proposed as pathogenic effectors driving disease recurrence.
- Results provide biomarkers for improved monitoring and prediction of relapse in IgG4-RD clinical practice.