Dynamics of phage-host interactions in Bacteroides fragilis resolved by single-cell transcriptomics - PubMed
6 hours ago
- #single-cell transcriptomics
- #Bacteroides fragilis
- #phage-host interactions
- Study uses single-cell RNA sequencing to analyze phage-host interactions in Bacteroides fragilis.
- Identifies phenotypic subpopulations of bacteria resistant to phage infection.
- Infection susceptibility influenced by phase-variable capsular polysaccharide (CPS) biosynthesis pathways and fimbrial gene operon.
- Reveals genome-wide phase variation and stochasticity as bacterial defense mechanisms.
- Establishes bacterial single-cell RNA sequencing as a tool for studying host-phage dynamics.