RIPK3 sequentially recruits MLKL and RIPK1 to induce PANoptosis and chemokine production - PubMed
6 hours ago
- #PANoptosis
- #Cell Death
- #RIPK3
- RIPK3 activation triggers MLKL phosphorylation, caspase activation, and gasdermin cleavage, leading to PANoptosis.
- Sequential recruitment of MLKL and RIPK1 to RIPK3 aggregates occurs based on differential affinities for RIPK3 oligomeric states.
- Cross-regulation between pathways modifies cellular morphology, DAMPs release, and chemokine secretion, distinct from classical cell death pathways.
- The RIPK3 complex acts as a platform to integrate different programmed cell death pathways, offering a target for inflammatory diseases.