Illuminating proinflammatory myeloid cells with PET tracers targeting GPR84 - PubMed
3 hours ago
- #GPR84 biomarker
- #neuroinflammation
- #PET imaging
- GPR84 is a biomarker upregulated on activated microglia and macrophages during chronic inflammation.
- Two fluorine-18 PET tracers, [18F]MGX-110S and [18F]MGX-111S, were developed for imaging GPR84.
- [18F]MGX-110S showed superior affinity, selectivity, and signal-to-background ratio for detecting myeloid cell activation.
- The tracer effectively visualized systemic and neuroinflammation in mouse models, outperforming existing methods.
- Clinical translation could improve detection and monitoring of inflammatory and neurodegenerative diseases.