Overcoming the blood‒brain barrier: nanomedicine strategies for targeted delivery and multimodal therapy in Alzheimer's disease - PubMed
5 hours ago
- #Alzheimer's disease
- #drug delivery
- #nanomedicine
- Nanomedicine offers promising strategies to overcome the blood-brain barrier (BBB) for Alzheimer's disease (AD) treatment.
- Key strategies include surface engineering and use of nanocarriers like liposomes, exosomes, dendrimers, and carbon dots.
- Stimuli-responsive release mechanisms (pH, enzymes, ROS, light, ultrasound) enable targeted drug delivery.
- Multifunctional nanoplatforms address multiple AD pathogenic pathways simultaneously (amyloid-β, tau aggregation, oxidative stress, etc.).
- Clinical translation faces challenges like biocompatibility, scalable manufacturing, patient heterogeneity, and regulatory hurdles.