DHODH-Mediated Suppression of Ferroptosis Supports Radioresistance and Represents a Therapeutic Vulnerability in Lung Cancer - PubMed
5 hours ago
- #Radioresistance
- #Ferroptosis
- #DHODH
- DHODH expression is induced by radiation via CREB, linking elevated DHODH activity to radioresistance.
- DHODH promotes radioresistance by generating ubiquinol to suppress ferroptosis and aiding DNA repair through pyrimidine synthesis.
- Combining DHODH inhibition with IFN-γ or anti-PD-1 immunotherapy synergistically enhances radiation-induced ferroptosis and overcomes radioresistance.
- This study identifies DHODH-mediated ferroptosis suppression as a therapeutic vulnerability in lung cancer.