Neuronal tetraspanin TSP-6 suppresses intestinal innate immunity by modulating dense-core vesicle release in Caenorhabditis elegans - PubMed
4 hours ago
- #Neuroimmune Regulation
- #Innate Immunity
- #Tetraspanin
- TSP-6, a neuronal tetraspanin, suppresses intestinal innate immunity in C. elegans by regulating dense-core vesicle release.
- Knockdown or knockout of tsp-6 enhances resistance to Pseudomonas aeruginosa PA14, with rescue in AWA neurons reversing this effect via UNC-31-dependent vesicle release.
- TSP-6 modulates immunity through DAF-16/FOXO and p38 MAPK pathways, indicating a role in neuro-immune crosstalk.