tRNA-derived RNA processing in sperm transmits non-genetically inherited phenotypes to offspring in C. elegans - PubMed
6 hours ago
- #C. elegans
- #epigenetics
- #sperm RNA
- tRNA-derived RNAs (tDRs) in sperm transmit non-genetically inherited phenotypes to offspring in C. elegans.
- The RNaseT2 enzyme, rnst-2, regulates tDR accumulation by processing tRNA-halves into short fragments.
- Regulation of tDR length distribution by rnst-2 modulates gene expression in early embryos, leading to adaptive phenotypes in progeny.
- tDRs are identified as a conserved carrier of intergenerational epigenetic information.
- C. elegans serves as a model for studying paternal non-genetic inheritance mechanisms.
- The study highlights the role of environmental factors in modulating epigenetic information in gametes.