Single-cell transcriptomic mendelian randomization and co-localization reveal immune-mediated regulatory mechanisms and drug targets in atopic dermatitis - PubMed
5 hours ago
- #Mendelian randomization
- #Drug targets
- #Atopic dermatitis
- Single-cell transcriptomic mendelian randomization and co-localization reveal immune-mediated regulatory mechanisms in atopic dermatitis (AD).
- Integration of sc-eQTL data from 14 immune cell types with AD GWAS summary statistics identified 14 immune cell-specific hub genes.
- Enrichment analysis showed significant clustering in MHC class II protein complexes and immune-related pathways.
- 46 drugs targeting these genes were identified, with 13 causal genes overlapping known druggable targets.
- The study provides genetic evidence supporting a causal role for immune cell-specific genes in AD susceptibility.