Recovery From Heart Failure: Microvascular Mechanisms - PubMed

5 hours ago

Heart failure (HF) is a major global health issue, with LVAD implantation serving as a bridge to heart transplantation.
LVAD support can improve cardiac histology and function, sometimes eliminating the need for transplantation after LVAD removal.
Post-LVAD myocardial tissues show reduced fibrosis and increased capillary density compared to pre-LVAD samples.
Single-nucleus RNA sequencing identified a fibroblast subset that undergoes mesenchymal-to-endothelial transition, contributing to vascular repair.
Nonmyocytes from post-LVAD hearts exhibit greater proliferation and angiogenesis capacity, forming vessel-like structures.
c-Myc plays a key role in regulating fibroblast-to-endothelial cell fate transition, offering potential for regenerative therapies in HF.

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