Central and Peripheral Neuromodulators in Functional Dyspepsia and Gastroparesis: A Symptom-Based Clinical Review - PubMed
6 hours ago
- #gastroparesis
- #functional dyspepsia
- #neuromodulators
- Functional dyspepsia (FD) and gastroparesis (GP) share overlapping upper gastrointestinal symptoms but differ in prevalence.
- First-line therapies like proton pump inhibitors often provide limited relief, leading to interest in neuromodulators.
- Central neuromodulators (e.g., tricyclic antidepressants, mirtazapine) are effective for epigastric pain syndrome (EPS).
- Peripheral neuromodulators (e.g., prokinetic agents) benefit postprandial distress syndrome (PDS) and GP, especially for nausea and early satiation.
- Treatment should be individualized based on symptom profile, drug safety, and comorbidities.
- A symptom-oriented approach with neuromodulators may optimize outcomes, but more subtype-specific trials are needed.