The vaccine platform used for COVID-19 primary immunization shapes the quality of the human B cell response to a vaccine boost - PubMed
6 hours ago
- #B cell response
- #COVID-19 vaccines
- #vaccine platforms
- The study explores how different COVID-19 vaccine platforms affect B cell responses to booster shots.
- An adenovirus vector prime followed by an mRNA boost showed the greatest short-term B cell expansion and elicited an activated atypical B cell subset linked to higher antibody binding titers.
- An mRNA primary series with a homologous boost induced a different B cell subset with more proliferative potential and higher frequencies of long-lived resting memory B cells.
- IgA-expressing memory B cells had more somatic hypermutations than IgG-expressing B cells, indicating varied immune responses.
- The findings suggest that combining different vaccine platforms could enhance both potency and durability of protection against infectious diseases.