Lipid signaling networks in pancreatic cancer progression and therapeutic perspectives - PubMed
7 hours ago
- #pancreatic cancer
- #lipid signaling
- #therapeutic targeting
- Lipid metabolism is crucial in pancreatic ductal adenocarcinoma (PDAC) progression, influencing signaling, stromal and immune interactions, metastasis, and treatment resistance.
- Key lipid classes involved include fatty acids, cholesterol, lysophospholipids, sphingolipids, and oxidized lipids, which intersect with oncogenic pathways like KRAS and PI3K-AKT.
- The review discusses therapeutic opportunities by targeting lipid-based vulnerabilities to overcome PDAC's aggressive nature and therapy resistance.