Ultrasound criteria for transmural healing and response in Crohn's disease: a systematic review of definitions and thresholds - PubMed
4 hours ago
- #Crohn's disease
- #intestinal ultrasound
- #transmural healing
- Transmural healing (TMH) indicates resolution of inflammation in all bowel wall layers and is an emerging therapeutic target in Crohn's disease (CD).
- Systematic review synthesizes published definitions for ultrasound-based assessment in CD, following PRISMA guidelines.
- In 83 studies analyzed, bowel wall thickness ≤ 3mm is most common TMH criterion (79% of studies), alongside absent/minimal Doppler flow (64%) and preserved stratification (26%).
- All transmural response (TMR) definitions require bowel wall thickness reduction, with thresholds varying (absolute ≥1mm or relative ≥25% in 73% of studies), plus Doppler improvement in 41%.
- Heterogeneity in definitions precludes quantitative pooling, highlighting lack of standardized ultrasound criteria for TMH and TMR in CD.