Olfactory Valence-Processing Deficits and Aberrant Brain Network Connectivity Underlie Social Dysfunction in Shank3-/- ASD Model Mice - PubMed
4 hours ago
- #Shank3
- #ASD
- #Olfactory Deficits
- Shank3-/- ASD model mice show deficits in olfactory valence processing, affecting their social behavior.
- Researchers used a modified olfactory three-chamber test, ultrasonic vocalization detection, rs-fMRI, c-Fos mapping, and 3D behavioral analysis to assess these mice.
- Findings include abnormal odor preference, hyperconnectivity in olfaction-related brain networks, and atypical whole-brain c-Fos activation patterns.
- The study links olfactory deficits to autism-like behaviors, suggesting the olfactory system as a target for sensory-based autism therapies.