ATG2A connects lipid droplets and the ER to regulate lipid storage - PubMed
5 hours ago
- #ER quality control
- #ATG2A
- #lipid droplets
- ATG2A connects lipid droplets (LDs) and the endoplasmic reticulum (ER) to regulate lipid storage.
- ATG2A transfers diacylglycerol (DAG), triacylglycerol (TAG), and phosphatidic acid (PA) from the ER to LDs.
- ATG2A recruits the TAG synthesis enzyme DGAT2 to promote LD expansion.
- Without ATG2A, lipids accumulate in the ER, leading to smaller, more numerous nucleated LDs.
- ATG2A-mediated DAG transfer enables local TAG synthesis, preventing nonmembrane lipid accumulation in the ER.
- ATG2A has a dual role in both autophagy and lipid storage, linking autophagy machinery to lipid storage.