NMN/NAD+ enhances SIRT2-modulated microtubule dynamics to improve mitochondrial and mitophagy functions in senescent cells - PubMed
4 hours ago
- #microtubule dynamics
- #mitochondrial function
- #cellular senescence
- NMN/NAD+ enhances SIRT2 activity to restore microtubule dynamics in senescent cells.
- Senescent muscle cells show microtubule hyper-stabilization, reduced dynamics, SIRT2 inactivation, and tubulin hyperacetylation.
- Impaired microtubule-dependent mitochondrial repair and mitophagy lead to mtDNA leakage and CGAS-STING1 activation, accelerating senescence.
- NMN treatment reactivates SIRT2, improves microtubule dynamics, and enhances mitochondrial quality control through repair and mitophagy.
- This reduces CGAS-STING1-driven senescence, revealing a novel SIRT2-microtubule axis for mitochondrial health beyond typical NAD+-sirtuin pathways.
- Microtubule dynamics is suggested as a therapeutic target for mitochondrial and mitophagy dysfunctions.