CD19+Ki67+B cells regulated by NAMPT as key modulators in triple-negative breast cancer with brain metastasis - PubMed
14 hours ago
- #B cells
- #Triple-negative breast cancer
- #Brain metastasis
- CD19+Ki67+B cells are key modulators in triple-negative breast cancer (TNBC) with brain metastasis.
- Single-cell RNA sequencing revealed enrichment of cycling B cells in metastatic TNBC.
- High abundance of CD19+Ki67+B cells correlates with poor overall survival.
- CD19+Ki67+B cells enhance TNBC organoid proliferation, invasion, and metastatic potential.
- NAMPT/ITGA5/ITGB1 signaling pathway activation is critical for B cell-cancer cell crosstalk.
- Findings provide insights into immune regulation of TNBC brain metastasis and potential therapeutic targets.