Randomized Trial of Adjunctive Prednisolone for Kawasaki Disease - PubMed
5 hours ago
- #Kawasaki Disease
- #Prednisolone
- #Coronary Lesions
- The study investigated whether adding prednisolone to standard treatment for Kawasaki disease reduces coronary-artery lesions.
- It was a randomized, controlled trial involving 3208 participants in China, comparing prednisolone plus standard treatment versus standard treatment alone.
- Primary outcome: incidence of coronary-artery lesions at 1 month showed no significant difference (16.0% vs. 13.8%, p=0.31).
- Secondary outcomes: prednisolone group had lower rescue therapy use (4.6% vs. 10.1%), shorter fever duration (8.4 vs. 13.2 hours), and greater CRP reduction at 72 hours.
- No significant difference in coronary-artery lesion progression or aneurysm incidence at 3 months, and adverse events were similar between groups.
- Conclusion: Adjunctive prednisolone did not reduce coronary-artery lesions at 1 month, though it improved some secondary markers.