A sympathetic-eosinophil axis orchestrates psychological stress to exacerbate skin inflammation - PubMed
5 hours ago
- #stress
- #neuroimmunology
- #dermatitis
- Psychological stress exacerbates dermatitis through a neurobiological mechanism.
- A subset of Pdyn+ noradrenergic sympathetic neurons innervates hairy skin, mediating stress-induced skin inflammation.
- Stress-induced inflammation is eosinophil-dependent, with genetic ablation of Pdyn+ neurons or eosinophils mitigating inflammation.
- Optogenetic activation of Pdyn+ sympathetic neurons worsens inflammation via eosinophils.
- Pdyn+ neurons recruit eosinophils through the CCL11-CCR3 axis and activate them via Adrb2 in inflamed skin.
- The study highlights the Pdyn+ sympathetic-eosinophil axis as a critical brain-skin inflammation interface with therapeutic potential.