Liquiritin attenuates IONI-induced trigeminal neuropathic pain via TLR4/MyD88-dependent modulation of microglial M1-like polarization - PubMed
6 hours ago
- #Neuropathic Pain
- #Microglial Polarization
- #TLR4/MyD88 Signaling
- Liquiritin, a flavonoid from licorice, reduces trigeminal neuropathic pain induced by infraorbital nerve injury (IONI) in mice.
- The mechanism involves suppression of microglial M1-like polarization and down-regulation of TLR4/MyD88 signaling, leading to decreased inflammatory cytokines (IL-1β, TNF-mall α) and pain mediators (CGRP, TRPV1).
- In vivo and in vitro studies confirm Liquiritin's effects on pain behaviors and molecular markers, supported by network pharmacology and molecular docking data.
- Preliminary safety assessment shows no significant liver enzyme changes at therapeutic doses, though serum creatinine increased, warranting further long-term safety studies.