PGAM1-dependent VDAC1 oligomerization disrupts mitochondrial quality control to drive doxorubicin cardiotoxicity via the cGAS-STING-ferroptosis axis - PubMed
3 months ago
- #Doxorubicin
- #Cardiotoxicity
- #Ferroptosis
- Doxorubicin (Dox) cardiotoxicity is linked to PGAM1-dependent VDAC1 oligomerization.
- PGAM1 upregulation by Dox disrupts mitochondrial quality control (MQC) and induces ER stress.
- Mitochondrial DNA (mtDNA) leakage activates the cGAS-STING pathway, leading to ferroptosis.
- PGAM1 knockout (PGAM1-CKO) mice show protection against Dox-induced cardiac dysfunction.
- Targeting the PGAM1/VDAC1 axis may mitigate Dox-induced cardiac injury.