Cellular circadian period and its deviation associate with Alzheimer's pathology and brain aging in cognitively impaired older adults - PubMed
6 hours ago
- #Alzheimer's disease
- #circadian rhythm
- #neurodegeneration
- Cellular circadian period and its deviation (Δ-period) were measured in dermal fibroblasts from 135 older adults with cognitive complaints.
- Longer intrinsic circadian period was associated with higher levels of Alzheimer's disease (AD)-related biomarkers (pTau-217, NfL, GFAP) and medial temporal atrophy.
- Greater Δ-period was linked to older age, poorer cognitive performance, and widespread brain atrophy, indicating broader aging-related neurodegeneration.
- Both longer circadian period and greater Δ-period independently predicted faster clinical decline in older adults with cognitive concerns.
- The study suggests cellular circadian properties can serve as complementary biomarkers for AD-related tau pathology and aging-related neurodegeneration.