Curcumol alleviates acute pancreatitis by inhibiting RIPK1/RIPK3/MLKL pathway-mediated necroptosis: integrated bioinformatics, network pharmacology, molecular docking and dynamics simulations, and exp
5 hours ago
- #acute-pancreatitis
- #necroptosis
- #curcumol
- Curcumol (CCM) alleviates acute pancreatitis (AP) by inhibiting necroptosis through the RIPK1/RIPK3/MLKL pathway.
- Integrated methods including bioinformatics, network pharmacology, and experiments showed necroptosis is enriched in AP and CCM binds stably to RIPK1.
- CCM dose-dependently reduces phosphorylation of RIPK1, RIPK3, and MLKL, suppressing necroptosis in pancreatic acinar-like cells.
- This study provides the first evidence for CCM's therapeutic potential in AP by targeting necroptosis.