T cell lymphomas: cancers of aberrant immune synapse signalling - PubMed
5 hours ago
- #oncology
- #T cell lymphoma
- #immune synapse
- Peripheral T cell lymphomas (PTCLs) are aggressive cancers from mature T cells.
- They often hijack signaling pathways of T cell activation at the immune synapse.
- Gain-of-function alterations in TCR regulators and NF-κB promote tumor growth.
- Mutations in co-stimulatory receptors and cytokine signaling contribute to malignancy.
- Loss-of-function in PDCD1 or PD1 disruption acts as a tumor-suppressor mechanism.
- PTCLs are viewed as cancers of aberrant immune synapse signaling.
- Genetic insights into PTCLs can inform the development of new T cell therapies.