NAT10/ac4C drives intrahepatic cholangiocarcinoma by suppressing transposable elements via chromatin remodeling - PubMed
3 hours ago
- #RNA modification
- #cancer therapy
- #epigenetic silencing
- NAT10-mediated ac4C modification stabilizes CHAF1A mRNA, which epigenetically silences the transposable element HERV9NC.
- This silencing reduces double-stranded RNA accumulation, promoting ICC proliferation, migration, and creating an immunosuppressive tumor microenvironment.
- Pharmacological inhibition of NAT10 shows therapeutic efficacy in ICC models, highlighting it as a druggable target.