Cell-based cancer immunotherapy: milestones, mechanistic insights, and emerging therapeutic directions - PubMed
2 hours ago
- #cell-based therapy
- #cancer immunotherapy
- #clinical advancements
- Cell-based immunotherapies are transformative in cancer treatment, complementing conventional methods like surgery and chemotherapy.
- Key modalities include CAR T cells, TCR-engineered T cells, tumor-infiltrating lymphocytes (TILs), dendritic cell vaccines, NK cell therapies, and macrophage-directed strategies.
- Mechanistic foundations, clinical outcomes in hematologic malignancies and solid tumors, and evaluation of toxicities, resistance, and response barriers are discussed.
- Emerging strategies focus on overcoming antigen escape, immunosuppressive tumor microenvironments, and challenges in manufacturing, scalability, and accessibility.
- These advances position cell-based immunotherapies as central to precision oncology, with potential for durable clinical benefit across diverse cancers.