Prenatal antiseizure drug exposure and risk of neurodevelopmental disorders in children: population based cohort study - PubMed
14 hours ago
- #prenatal exposure
- #antiseizure drugs
- #neurodevelopmental disorders
- Prenatal exposure to antiseizure drugs was studied for its association with neurodevelopmental disorders in children.
- The study used data from publicly and commercially insured beneficiaries in the U.S. from 2000-21.
- Valproate and zonisamide showed significant associations with increased risks of neurodevelopmental disorders.
- Levetiracetam and phenytoin were not associated with increased risks of any neurodevelopmental outcomes.
- Carbamazepine and oxcarbazepine showed modest risk increases for ADHD and behavioral disorders.
- Topiramate and lamotrigine had potential signals for intellectual disability and learning difficulties.
- The study emphasizes the need for further evaluation of zonisamide and confirms risks associated with valproate.