Liver-derived complement component 3 promotes the susceptibility to stress-induced depression by impairing blood-brain barrier integrity - PubMed
7 hours ago
- #Depression
- #Complement Component 3
- #Blood-Brain Barrier
- Liver-derived complement component 3 (C3) increases susceptibility to stress-induced depression.
- C3 impairs blood-brain barrier (BBB) integrity by inhibiting claudin-5 in endothelial cells.
- Genetic ablation or knockdown of hepatic C3 improves depressive-like behavior.
- Overexpression of hepatic C3 induces depressive-like behavior under stress.
- C3a receptor-CCAAT/enhancer-binding protein-α signaling mediates the effect.
- Corticosterone activates NF-κB to upregulate hepatic C3 release.
- Targeting hepatic C3 could be a therapeutic strategy for depression.