Leishmania Extracellular Vesicles as a Preventive Vaccine Platform Against Leishmaniasis - PubMed
5 hours ago
- #extracellular vesicles
- #adjuvant impact
- #leishmaniasis vaccine
- Leishmania extracellular vesicles (EVs) show potential as a preventive vaccine platform against leishmaniasis.
- Immunization with EVs from Leishmania major and Leishmania infantum elicits strong humoral and cellular immune responses, providing protection and cross-protection in mouse models.
- The choice of adjuvant significantly affects vaccination outcomes, influencing whether protection or susceptibility occurs.
- The study employs a production and purification method designed to aid clinical translation and affordable vaccine development.
- EVs could have broader applications in combating other protozoan infections beyond leishmaniasis.