PRMT5 inhibition sensitizes B-cell lymphoma cells to ferroptosis - PubMed
5 hours ago
- #Ferroptosis
- #PRMT5
- #B-cell lymphoma
- PRMT5 inhibition sensitizes B-cell lymphoma cells (DLBCL, MCL) to ferroptosis by targeting the SLC7A11 pathway.
- The AKT-MYC-ATF5 axis mediates PRMT5's role in upregulating SLC7A11, promoting cystine import and GSH synthesis to suppress ferroptosis.
- ATF5 induces SLC7A11 and ATF4 expression, forming heterodimers to reinforce a regulatory network against ferroptosis.
- Combining PRMT5 inhibitor GSK3326595 with ferroptosis inducer DMF shows synergistic anti-tumor activity in a PDX model.