PTBP1 knockdown reprograms glioma stem cells into neuronal-like cells and suppresses tumorigenesis via the DUSP5-ERK1/2 signaling pathway - PubMed
5 hours ago
- #nanotherapy
- #PTBP1 knockdown
- #glioma stem cells
- PTBP1 knockdown reprograms glioma stem cells into neuronal-like cells, suppressing tumorigenesis via the DUSP5-ERK1/2 pathway.
- Clinically, glioma cell morphology correlates with patient survival, and PTBP1 post-transcriptionally regulates DUSP5 to modulate ERK1/2 phosphorylation.
- A nanotherapeutic strategy using A2-PLGA/venetoclax effectively targets PTBP1, crosses the blood-brain barrier, and inhibits glioma growth in mouse models.