Neuronutrition in ASD: Involvement of gut microbiota, oxidative stress and inflammatory markers - PubMed
4 hours ago
- #gut microbiota
- #autism spectrum disorder
- #neuronutrition
- Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social impairments, repetitive behaviors, and emotional dysregulation.
- Children with ASD often experience gastrointestinal issues and gut microbiota dysbiosis, with inflammation and oxidative stress being key contributors.
- Probiotics, particularly Lactobacillus and Bifidobacterium, have shown effectiveness in improving behavioral symptoms and GABA/glutamate balance in both human and rodent studies.
- Combining probiotics with prebiotics, dietary interventions, microbiota transfer therapies, and exercise can enhance gastrointestinal and behavioral outcomes in ASD.
- Current limitations in neuronutrition research include small sample sizes, cross-sectional designs, and heterogeneous populations, necessitating precision diets tailored to individual microbiome profiles.
- Integrating metagenomics, metabolomics, epigenomics, and environmental assessments holds promise for improving ASD management and quality of life.