SIRT3-mediated deacetylation of FoxM1 prevents pulmonary fibrosis via modulating the activation of pulmonary fibroblasts - PubMed
4 days ago
- #FoxM1
- #SIRT3
- #pulmonary fibrosis
- FoxM1 is highly expressed in activated pulmonary fibroblasts and its nuclear translocation is crucial for resistance to FasL-induced apoptosis.
- Disruption of FoxM1 function helps resolve fibrosis in bleomycin-treated mice.
- Decreased SIRT3 expression leads to increased FoxM1 acetylation, essential for pulmonary fibroblast activation.
- Downregulation of SIRT3 enhances FoxM1 stability, accelerating bleomycin-induced pulmonary fibrosis.
- Nicotinamide riboside treatment suppresses pulmonary fibroblast activation and protects against bleomycin-induced fibrosis by activating SIRT3.
- The SIRT3/FoxM1 axis plays a critical role in regulating pulmonary fibroblast activation, suggesting potential therapeutic strategies for pulmonary fibrosis.