Subcellular localization as a driver of protein function - PubMed
4 days ago
- #spatial biology
- #protein localization
- #moonlighting
- Subcellular localization is crucial for protein function, influencing processes like signal transduction, metabolism, and cell cycle.
- Multilocalization allows identical protein sequences to perform multiple functions (moonlighting).
- Mechanisms of protein localization include RNA transport, proteoforms, and molecular interactions.
- Proper localization regulation is vital for cell differentiation, polarization, and epithelial-mesenchymal transition.
- Mislocalization can contribute to diseases such as cancer, neurodegeneration, and autoimmunity.
- Technological and conceptual challenges in subcellular proteomics and spatial biology need addressing to understand protein localization dynamics.