Anti-phospholipid antibodies as a risk factor for renal injury in patients with systemic lupus erythematosus: a comprehensive analysis - PubMed
2 days ago
- #systemic lupus erythematosus
- #anti-phospholipid antibodies
- #renal injury
- Anti-phospholipid antibodies (aPL) are investigated as a risk factor for renal injury in systemic lupus erythematosus (SLE) patients.
- A meta-analysis of 70 studies involving 12,456 SLE patients found a significant association between aPL and renal injury, with a pooled OR of 2.09.
- Subgroup analyses identified anti-cardiolipin (aCL) and lupus anticoagulant (LA) as significant contributors to renal injury risk, with ORs of 1.71 and 2.43, respectively.
- No significant risk increase was observed for anti-β2-glycoprotein I and aPS/PT antibodies.
- The study concludes that aPL seropositivity, particularly LA and aCL, significantly increases renal injury risk in SLE patients.