Extracellular vesicle miR-93-5p cargo regulates glomerular endothelial cell damage in Alport syndrome - PubMed
5 hours ago
- #miR-93-5p
- #Alport syndrome
- #extracellular vesicles
- miR-93-5p is downregulated in glomerular endothelial cells in Alport syndrome.
- Extracellular vesicles from human amniotic fluid stem cells (hAFSC-EVs) carry miR-93-5p, which helps mitigate glomerular damage.
- Silencing miR-93-5p in hAFSC-EVs reduces their ability to restore kidney function and endothelial cell biology.
- hAFSC-EVs regulate VEGFR1 and VEGFR2 signaling through miR-93-5p transfer.
- Spatial transcriptomics shows hAFSC-EVs reverse disease progression pathways, particularly in the glomerulus.
- miR-93-5p targets are altered in Alport syndrome patient biopsies, confirming its role in disease.