Association of Clonal Hematopoiesis with Incident, Late-Onset, Seropositive Rheumatoid Arthritis - PubMed
5 hours ago
- #Complement Pathway
- #Rheumatoid Arthritis
- #Clonal Hematopoiesis
- Clonal hematopoiesis (CH) is linked to inflammatory diseases of aging, including rheumatoid arthritis (RA).
- CHIP and mCA subtypes, particularly DNMT3A-mutated CHIP, autosomal mCA, and mLOY, increase the risk of seropositive RA (SPRA) but not seronegative RA (SNRA).
- Higher genetically predicted levels of complement proteins C1r and C1s reduce the association between CHIP and SPRA.
- The study involved 612,989 participants, identifying 30,840 with CHIP and 1,535 with incident SPRA.
- Findings suggest a genotype- and serostatus-specific connection between somatic mutations and RA, with the classical complement pathway as a potential modifier.