Single-nucleus epigenomic dysregulation unmasks genetic risk-associated neurodegenerative glia states - PubMed
3 days ago
- #epigenomics
- #glia
- #neurodegeneration
- This study uses single-nucleus profiling to explore epigenetic and gene expression changes in tau-related dementias (Alzheimer's, Pick's disease, PSP).
- It finds glial cells prominently show disorder-specific gene regulation linked to stress response.
- Genetic risk variants affecting microglial regulation cluster into functional modules, and polygenic risk modifiers are most active in disorder-specific glial states.
- Pathways like sphingomyelin regulation in Pick's disease are modified, highlighting potential modifiable resilience pathways.