The natural flavonoid dihydromyricetin targets senescent cells via PRDX2 and alleviates age-related diseases - PubMed
3 days ago
- #aging
- #flavonoid
- #senescence
- Dihydromyricetin, a natural flavonoid, targets senescent cells via PRDX2.
- It acts as a senomorphic agent, protecting senescent fibroblasts from DNA damage and reducing the senescence-associated secretory phenotype.
- Proteomics indicates dihydromyricetin promotes PRDX2 nuclear translocation to aid DNA repair in senescent cells.
- In prematurely aged mice, dihydromyricetin mitigates tissue aging and physiological decline.
- It improves chemotherapy outcomes in anticancer regimens.
- Dihydromyricetin exhibits senolytic activity against senescent microglial cells with low PRDX2 expression, impairing mitochondrial function to induce apoptosis.
- In Alzheimer's disease mice, it removes senescent microglial cells from amyloid β-protein plaques and alleviates neurodegenerative symptoms.
- The study suggests dihydromyricetin as a natural senotherapeutic for age-related diseases like cancer and Alzheimer's.