Two-Year Outcomes of Less Invasive Surfactant Administration Among Preterm Neonates: A Secondary Analysis of a Randomized Clinical Trial - PubMed
17 hours ago
- #LISA
- #Preterm Neonates
- #Neurodevelopmental Outcomes
- A secondary analysis of a randomized trial examined two-year outcomes in preterm neonates receiving less invasive surfactant administration (LISA) plus early caffeine, compared to CPAP alone.
- The primary outcome, death or moderate to severe neurodevelopmental impairment (NDI) at a corrected age of 2 years, did not show a significant reduction with LISA (23.0% vs. 32.9%, OR 1.56, p=0.22).
- On developmental screening (ASQ-3), LISA infants had a higher likelihood of fine motor scores in the reference range, but no significant differences in typical development rates or scores indicating possible delay.
- No significant differences were found in pulmonary outcomes, including bronchodilator use, corticosteroid use, or post-discharge respiratory hospitalizations between groups.
- The study concluded that early caffeine plus LISA did not reduce death or moderate to severe NDI, but may benefit fine motor development as measured by ASQ-3.